FlyBase Allele Report: Dmel\Sb[Ebr228]

General Information

Symbol

Dmel\Sb^Ebr228

Species

D. melanogaster

Name

FlyBase ID

FBal0155917

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ward et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | recessive

(Ward et al., 2003)

lethal | larval stage | recessive

(Ward et al., 2003)

partially lethal

(Ward et al., 2003)

visible | recessive

(Ward et al., 2003)

Phenotype Manifest In

chaeta

(Ward et al., 2003)

Detailed Description

Statement

Reference

Heterozygotes do not show a malformed leg phenotype. Heterozygotes have normal bristle morphology. Homozygous adults are produced at about 20% of the expected frequency, and they have a completely penetrant stubble bristle phenotype. Homozygotes show 7 +/- 3% embryonic lethality and 34 +/- 10% of homozygous larvae fail to form pupae. Homozygotes show larval moulting defects.

(Ward et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sb[+]/Sb^Ebr228 is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sb[+]/Sb^Ebr228 is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

5% of br¹ ; Sb^Ebr228/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; Sb^Ebr228/+ flies is short, fat femurs and tibias. 0% of br⁵/+ ; Sb^Ebr228/+ flies show a malformed leg phenotype. 3% of Sb^Ebr228 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 12% of Sb^Ebr228 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 2% of Sb^Ebr228 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 4% of Sb^Ebr228 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 2% of Sb^Ebr228 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 14% of Sb^Ebr228 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 0% of Sb^Ebr228 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 0% of Sb^Ebr228 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg.