FB2026_02 , released June 18, 2026
Allele: Rat\CaMKIINαI.UAS.cHa
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General Information
Symbol
Rat\CaMKIINαI.UAS.cHa
Species
R. unknown
Name
FlyBase ID
FBal0155989
Feature type
allele
Associated gene
Rat\CaMKIINα
Associated Insertion(s)
Carried in Construct
P{UAS-CaMKIINα.I}
Also Known As
UAS-CaMKIINtide
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Haghighi et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-CaMKIINα.I}
Cytology
Description

Expression of the inhibitory domain of Rat\CaMKIINα (MKRPPKLGQIGRSKRVVIEDDRIDDVLK) is under the control of UASt sequences.

(Haghighi et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rat\CaMKIINα
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In neuromuscular junctions of Rat\CaMKIINαI.Scer\UAS.cHa; Scer\GAL4Mhc.PW larvae, quantal content is significantly greater than wild-type. When 2 copies of Rat\CaMKIINαI.Scer\UAS.cHa are present quantal content is increased further and there is a significant increase in excitatory postsynaptic potential (EPSP) amplitude and in mini-EPSP frequency. Mini-EPSP amplitude and kinetics are unaffected as is membrane potential and input resistance of the muscles. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae).

      (Haghighi et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      witHA4/witHA5 suppresses the increase in the excitatory postsynaptic potential amplitude seen in the neuromuscular junctions of Rat\CaMKIINαI.Scer\UAS.cHa; Scer\GAL4C142 larvae. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae).

      (Haghighi et al., 2003)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rat\CaMKIINαI.Scer\UAS.cHa
      Rat\CaMKIINαI.UAS.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)