FlyBase Allele Report: Dmel\Mef2[25-42]

General Information

Symbol

Dmel\Mef2^25-42

Species

D. melanogaster

Name

FlyBase ID

FBal0156257

Feature type

allele

Associated gene

Dmel\Mef2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Goldstein et al., 2001)

diepoxybutane

(Goldstein et al., 2001)

gamma ray

(Goldstein et al., 2001)

Progenitor genotype

Cytology

Description

A mutation with the conserved MADS box of Mef2 results in a loss of DNA binding ability.

(Nguyen et al., 2002)

Amino acid replacement: R17W.

(Nguyen et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:9,921,615..9,921,615 [-]

Nucleotide change:

C9921615T

Amino acid change:

Reported amino acid change:

R17W

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Nguyen et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)X1)

(Goldstein et al., 2001)

lethal (with Mef2^22-21)

(Baker et al., 2005)

lethal (with Mef2^22-24)

(Baker et al., 2005)

lethal (with Mef2^25-34)

(Baker et al., 2005)

lethal (with Mef2^26-6)

(Baker et al., 2005)

lethal (with Mef2^26-7)

(Baker et al., 2005)

lethal (with Mef2^26-49)

(Baker et al., 2005)

lethal (with Mef2^30-5)

(Baker et al., 2005)

lethal (with Mef2^44-5)

(Baker et al., 2005)

lethal (with Mef2^48-7)

(Baker et al., 2005)

lethal (with Mef2^66-25)

(Baker et al., 2005)

lethal (with Mef2^78-11)

(Baker et al., 2005)

lethal | recessive

(Baker et al., 2005)

partially lethal (with Mef2^55-5)

(Baker et al., 2005)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell (with Mef2⁶⁵)

(Nguyen et al., 2002)

embryonic/larval midgut

(Nguyen et al., 2002)

larval somatic muscle cell

(Nguyen et al., 2002)

Detailed Description

Statement

Reference

The embryonic dorsal vessel forms normally in homozygous Mef2^25-42 embryos. In contrast, there is a dramatic decrease in somatic musculature and malformed midguts in these mutant embryos.

Mef2^25-42/Mef2⁶⁵ trans-heterozygotes exhibit major defects in their indirect flight muscles, based on reduced numbers and abnormal patterning of the dorsal longitudinal indirect flight muscles.

(Nguyen et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

Mef2^55-5

(Baker et al., 2005)

Fails to complement

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

"ethyl methanesulfonate" was stated as tentative. "diepoxybutane" was stated as tentative. "γ ray" was stated as tentative.

(Goldstein et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

25-42

(Goldstein et al., 2001)

D-mef2^25-42

(Nguyen et al., 2002)

Mef2^25-42

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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