FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\HTTN548.Q0.UAS
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General Information
Symbol
Hsap\HTTN548.Q0.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0156387
Feature type
allele
Associated gene
Hsap\HTT
Associated Insertion(s)
Carried in Construct
P{UAS-hHTT.N548.Q0}
Also Known As
UAS-Htt-Q0, UAS-httQ0, Htt-Q0
Key Links
Transgenic product class
inframe_deletion
(Lee et al., 2004)
short_tandem_repeat_contraction
(Lee et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lee et al., 2004)
short_tandem_repeat_contraction
(Lee et al., 2004)
Mutagen
in vitro construct
(Lee et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-hHTT.N548.Q0}
Cytology
Description

UASt sequences drive expression of the N terminal 548 aa of the Q0 Hsap\HTT cDNA, which encodes the non-pathogenic protein.

(Lee et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\HTT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      DOES NOT model  Huntington's disease
      CEA
      (Lee et al., 2004)
      model of  Huntington's disease
      CEA
      (Nitta et al., 2023)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Hsap\HTTQ0.UAS under the control of Scer\GAL4P2.4.Pdf does not seem to have a major effect on circadian behavior, nor on the number of sLNv nurons in 10-days old adults.

      (Xu et al., 2019)

      Expressing Hsap\HTTQ0.UAS under the control of Scer\GAL4GMR.PF induces significant apoptosis (cleaved DCP1 labelling) in the eye disc, as compared to controls.

      (Coelho et al., 2018)

      Adult flies expressing Hsap\HTTQ0.Scer\UAS under the control of the Scer\GAL4P2.4.Pdf driver show robust locomotor activity in constant darkness (DD), with a longer period than in wild-type, which is also observed in the driver line alone. The oscillation of per protein in the somas of l-LNv neurons in DD shows very low amplitude.

      (Prakash et al., 2017)

      Expression of Hsap\HTTQ0.Scer\UAS under the control of Scer\GAL4GMR.PU does not result in eye defects.

      (Godin et al., 2010)

      When Hsap\HDQ0.Scer\UAS is driven by Scer\GAL4GMR.PF, no eye phenotype is seen. The neurophysiology also appears normal. When Hsap\HDQ0.Scer\UAS is driven by Scer\GAL4elav.PLu or Scer\GAL4elav-C155 no effect is seen in locomotor behaviour or life span.

      (Lee et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hsap\HTTN548.Q0.UAS, Scer\GAL4GMR.PF is a suppressor of eye | progressive phenotype of Scer\GAL4GMR.PF, httRNAi.UAS

      (Mugat et al., 2008)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The co-expression of Hsap\HTTQ0.UAS and Atx2KK100423 under the control of Scer\GAL4P2.4.Pdf leads to a moderate impairment of circadian behavior, as compared to Hsap\HTTQ0.UAS single expression and wild-type controls.

      The co-expression of Hsap\HTTQ0.UAS and Atx2ΔLsm.UAS.Tag:FLAG under the control of Scer\GAL4P2.4.Pdf leads to a moderate impairment of circadian behavior, as compared to the Hsap\HTTQ0.UAS single expression and wild-type controls.

      The co-expression of Hsap\HTTQ0.UAS and Atx2ΔPAM2.UAS.Tag:FLAG under the control of Scer\GAL4P2.4.Pdf can lead to a moderate impairment of circadian behavior, as compared to the Hsap\HTTQ0.UAS single expression and wild-type controls (this phenotype depends on the Atx2ΔPAM2.UAS.Tag:FLAG insertion).

      (Xu et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\HDQ0.Scer\UAS
      Hsap\HTTN548.Q0.UAS
      Hsap\HTTQ0.Scer\UAS
      Hsap\HTTQ0.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (16)