Open Close
General Information
Symbol
Dmel\SREBPNTdel.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156413
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Deleted for the highly acidic region at the N terminus (amino acids 1-75) and the transmembrane domains.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Upon being subjected to pacing-induced stress, hearts expressing HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand show lower rates of heart failure compared to control hearts at older ages (4 weeks).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The increased triglyceride levels seen in the hearts of 1 week old eas2 females are suppressed if they are also expressing HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand.

Expression of HLH106NTdel.Scer\UAS under the control of Scer\GAL4HCH.Hand significantly rescues the increased heartbeat rate, constricted heart phenotype and muscle defects of eas2 flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
HLH106NTdel.Scer\UAS
SREBPNTdel.Scer\UAS
SREBPNTdel.UAS
dSREBPDN75T
Name Synonyms
Secondary FlyBase IDs
    References (4)