FB2026_02 , released June 18, 2026
Allele: Dmel\Fmr11
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General Information
Symbol
Dmel\Fmr11
Species
D. melanogaster
Name
FlyBase ID
FBal0156456
Feature type
allele
Associated gene
Dmel\Fmr1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Lee et al., 2003)
Mutagen
ethyl methanesulfonate
(Lee et al., 2003)
Progenitor genotype
Fmr1EP3517
(Lee et al., 2003)
Cytology
Description

Contains am 11nt deletion that causes a frameshift that creates a stop codon after amino acid 289.

(Lee et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:10,105,826..10,105,836 [-]
Comment:

An 11bp deletion in the Fmr11 allele causes a frame-shift in the N terminus after amino acid 126; position of mutation on reference sequence inferred by FlyBase curator based on author statement.

(Lee et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fmr11/Fmr14.L wandering larvae have defects in crawling behaviour; they spend significantly less time on linear locomotion than wild-type control larvae and the average duration of linear locomotion is reduced compared to controls. The average direction change (direction change is defined as the difference in direction from one frame to the next in the analysis) is increased compared to controls.

      (Xu et al., 2004)

      No obvious morphological defects are seen in mutant adults.

      (Lee et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fmr11
      dfmr11
      (Xu et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)