FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Egfr::kek1KEgG.UAS.GFP
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General Information
Symbol
Dmel\Egfr::kek1KEgG.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0156486
Feature type
allele
Associated gene
Egfr::kek1
Associated Insertion(s)
Carried in Construct
P{UAS-kek1::Egfr.KEgG}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Alvarado et al., 2004)
Progenitor genotype
Egfr::kek1KEG.UAS.GFP
(Alvarado et al., 2004)
Carried in construct
P{UAS-kek1::Egfr.KEgG}
Cytology
Description

G901R mutation within the kinase domain, which disrupts ATP binding.

(Alvarado et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Egfr::kek1
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Egfr::kek1KEgG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4CY2 results in eggs with ventralised chorions. Expression of Egfr::kek1KEgG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

      (Alvarado et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Egfr::kek1KEgG.UAS.GFP, Scer\GAL4GMR.PF has visible phenotype, suppressible by Egfr[+]/EgfrSOK2

      (Alvarado et al., 2004)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Egfr::kek1KEgG.UAS.GFP, Scer\GAL4GMR.PF has eye phenotype, suppressible by Egfr[+]/EgfrSOK2

      (Alvarado et al., 2004)

      Egfr::kek1KEgG.UAS.GFP, Scer\GAL4GMR.PF has ommatidium phenotype, suppressible by Egfr[+]/EgfrSOK2

      (Alvarado et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The rough eye phenotype caused by expression of Egfr::kek1KEgG.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF is strongly suppressed by EgfrSOK2/+.

      (Alvarado et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid, transfected into S3 cells and used in coimmunoprecipitation assays.

      (Alvarado et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Egfr::kek1KEgG.Scer\UAS.T:Avic\GFP
      Egfr::kek1KEgG.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)