FlyBase Allele Report: Dmel\Ama[R1]

General Information

Symbol

Dmel\Ama^R1

Species

D. melanogaster

Name

FlyBase ID

FBal0157351

Feature type

allele

Associated gene

Dmel\Ama

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Liebl et al., 2003)

Progenitor genotype

Ama^M109

(Liebl et al., 2003)

Cytology

Description

In addition to the missense mutation, the deletion starts with the first base of the P114 codon and ends with the second base of the A123 codon. The 29 bases deleted are CCGTACGAGTGTCAGGTGCTTGTTTCGGC.

(Liebl, 2005.5.20)

Amino acid replacement: R103C. In addition to the R103C mutation, there is also a 29bp deletion beginning in the P114 codon, which results in a frameshift.

(Liebl et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:6,764,179..6,764,207 [+]

Comment:

29bp deletion which begins with the first base of codon P114. Causes a frameshift followed by 54 novel amino acid residues before early termination. The Ama^R1 allele also contains a R103C missense mutation.

(Liebl, 2005.5.20, Liebl et al., 2003)

point_mutation

3R:6,764,146..6,764,146 [+]

Nucleotide change:

C6764146T

Amino acid change:

R103C | Ama-PA; R111C | Ama-PB; R103C | Ama-PC

Reported amino acid change:

R103C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The Ama^R1 allele also contains a 29bp deletion beginning in codon P114, which causes a frameshift.

(Liebl et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Df(3R)ama/Ama^R1 is an enhancer of abnormal neuroanatomy phenotype of Abl⁴/Abl¹

(Liebl et al., 2003)

NOT Enhancer of

Statement

Reference

Ama^R1/Ama[+] is a non-enhancer of abnormal neuroanatomy phenotype of Abl⁴/Abl¹

(Liebl et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Df(3R)ama/Ama^R1 is an enhancer of larval ventral nerve cord commissure phenotype of Abl⁴/Abl¹

(Liebl et al., 2003)

NOT Enhancer of

Statement

Reference

Ama^R1/Ama[+] is a non-enhancer of larval ventral nerve cord commissure phenotype of Abl⁴/Abl¹

(Liebl et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

104% of the expected number of Abl¹ Ama^R1/Abl⁴ pupae are observed, while 67% of the expected number of Abl¹ Ama^R1/Abl⁴ adults are observed. 4% of segments have commissure defects in the central nervous system of Abl¹ Ama^R1/Abl⁴ embryos. 23% of segments have commissure defects in the central nervous system of Abl¹ Ama^R1/Abl⁴ Df(3R)ama embryos.

(Liebl et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

90305

Abl¹ Ama^R1/TM6B, Tb¹

Notes on Origin

Discoverer

Selected as: a revertant of the dominant enhancement by Ama^M109 of the Abl mutant phenotype.

(Liebl et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ama^R1

(Becker et al., 2016)

ama^R1

(Liebl et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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