FlyBase Allele Report: Dmel\lmgA[EY11317]

General Information

Symbol

Dmel\lmgA^EY11317

Species

D. melanogaster

Name

FlyBase ID

FBal0158999

Feature type

allele

Associated gene

Dmel\lmgA

Associated Insertion(s)

P{EPgy2}lmgA^EY11317

Carried in Construct

Also Known As

lmg^EY11317

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}lmgA^EY11317

Cytology

Description

The P{EPgy2}lmg^EY11317 insertion maps within a dicistronic processed transcript that encodes two non-overlapping open reading frames (lmg and CG34441).

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:8,528,459..8,528,459 [-]

(Weber and Mlodzik, 2017, Nagy et al., 2012, Gene Disruption Project members, 2001-, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | third instar larval stage

(Nagy et al., 2012)

increased cell death | third instar larval stage

(Nagy et al., 2012)

increased occurrence of cell division | third instar larval stage

(Nagy et al., 2012)

lethal - all die before end of prepupal stage

(Nagy et al., 2012)

some die during prepupal stage | recessive

(Nagy et al., 2012)

Phenotype Manifest In

larval brain | third instar larval stage

(Nagy et al., 2012)

wing disc | third instar larval stage

(Nagy et al., 2012)

Detailed Description

Statement

Reference

Homozygotes die at prepupal stage P4(ii). The mitotic index in third larval instar brains is increased compared to wild type and 26.6 +/- 3.1 % of the cells are polyploid. Third larval instar brains and wing imaginal discs show increased levels of apoptosis compared to wild type.

(Nagy et al., 2012)

Mutant embryos do not show defects in glial cell migration.

(Silies and Klämbt, 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(2R)Chi^g230, lmgA^EY11317 has lethal | recessive | embryonic stage phenotype

(Silies and Klämbt, 2010)

Df(2R)Chi^g230, lmgA^EY11317 has abnormal neuroanatomy | embryonic stage phenotype

(Silies and Klämbt, 2010)

Phenotype Manifest In

Other

Statement

Reference

Df(2R)Chi^g230, lmgA^EY11317 has larval glial cell phenotype

(Silies and Klämbt, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

lmg^EY11317 Df(2R)Chi^g230 double mutant embryos show defects in glial cell migration; glial cells accumulate close to the peripheral nervous system, and do not migrate into the periphery.

(Silies and Klämbt, 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

21361

y¹ w^67c23; P{EPgy2}lmgA^EY11317 lmgB^EY11317/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

lmg/APC11^EY11317

(Silies and Klämbt, 2010)

lmg^EY11317

(Neuert et al., 2017, Weber and Mlodzik, 2017, Nagy et al., 2012)

lmgA^EY11317

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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