FlyBase Allele Report: Dmel\Cul1[EY11668]

General Information

Symbol

Dmel\Cul1^EY11668

Species

D. melanogaster

Name

FlyBase ID

FBal0159000

Feature type

allele

Associated gene

Dmel\Cul1

Associated Insertion(s)

P{EPgy2}Cul1^EY11668

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Cul1^EY11668

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:7,916,993..7,916,993 [-]

(Zhou et al., 2007, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | larval stage (with Cul1^EX)

(Komori et al., 2018)

Phenotype Manifest In

embryonic/larval optic lobe | larval stage (with Cul1^EX)

(Komori et al., 2018)

type II neuroblast | increased number | larval stage (with Cul1^EX)

(Komori et al., 2018)

Detailed Description

Statement

Reference

Cul1^EX/Cul1^EY11668 transheterozygosity leads to supernumerary type II neuroblasts in the larval optic lobe.

(Komori et al., 2018)

Mutant embryos cultured under hypoxic conditions (5% O[[2]]) show increased eclosion compared to controls raised under the same conditions.

(Zhou et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Cul1^EX/Cul1^EY11668 has increased cell number | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

NOT Enhancer of

Statement

Reference

Cul1^EY11668, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul1^EY11668, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Phenotype Manifest In

Enhanced by

Statement

Reference

Cul1^EX/Cul1^EY11668 has type II neuroblast | larval stage | increased number phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

Cul1^EX/Cul1^EY11668 has embryonic/larval optic lobe | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

NOT Enhancer of

Statement

Reference

Cul1^EY11668, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul1^EY11668, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20813

y¹ w^67c23; P{EPgy2}Cul1^EY11668/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cul1^EY11668

cul1^EY11668

(Komori et al., 2018)

lin19^EY11668

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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