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General Information
Symbol
Dmel\Cul1EX
Species
D. melanogaster
Name
FlyBase ID
FBal0141058
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Imprecise excision of a P-element insertion, resulting in a deletion that removes sequences encoding lin19 amino acids 1 to 90.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Adult flies carrying Cul1EX mutant clones in the wings have missing wing veins.

    All lin19EX mutant ddaC neuron clones exhibit severe dendrite pruning defects at 16 hours after puparium formation. No difference is seen at the white prepupal stage. lin19EX mutant clones in ddaD/E neurons also fail to prune their larval dendrites at 18 hours after puparium formation. Unlike in wild type lin19EX mutant ddaF clones survive until 16 hours after puparium formation.

    lin19EX mutant neuroblast clones result in mushroom body γ neurons retain many larval axons at 24 hours after puparium formation that are pruned in wild type. These axons persist into the adult brain. In wandering third instar larvae the dorsal and medial axons are projected normally but the axon branches are less dense than in wild type. All lin19EX mutant neuroblast clones lack late-born α/β neurons.

    lin19EX mutant clones in the third instar larval wing disc are very small and rarely observed.

    Homozygotes and lin19EX/Df(2R)CA53 animals die as second instar larvae.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    NOT Enhanced by
    Statement
    Reference
    Suppressed by
    Enhancer of
    Statement
    Reference
    NOT Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference
    Other
    Statement
    Reference
    Phenotype Manifest In
    NOT Enhanced by
    Suppressed by
    Enhancer of
    Statement
    Reference
    NOT Enhancer of
    Suppressor of
    Statement
    Reference

    Cul1EX/lin19[+] is a suppressor of eye | somatic clone phenotype of COX5Atend

    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Cul1EX heterozygosity does not significantly affect the ddaC neuron pruning defects observed in prd1M56/Df(3R)Exel7310 transheterozygous at 16h after puparium formation, namely the length of the persisting dendrites.

    Sox14Δ13 lin19EX double mutant ddaC neuron clones have similar dendrite pruning defects at 16 hours after puparium formation as are seen in either single mutant alone.

    Expression of InRK1409A.Scer\UAS under the control of Scer\GAL4ppk.PG fully strongly suppresses the dendrite pruning defects seen in lin19EX mutant ddaC neuron clones at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

    Expression of ThorT37A.T46A.Scer\UAS under the control of Scer\GAL4ppk.PG fully strongly suppresses the dendrite pruning defects seen in lin19EX mutant ddaC neuron clones at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

    A lin19EX heterozygous background does not suppress the disruptions in cell division seen in CoVatend mutant eye disc clones.

    Expression of one copy of ApplScer\UAS.cTa under the control of Scer\GAL4ap-md544 in a lin19EX/+ background results in loss of thoracic microchaetae.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    Expression of lin19Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4ppk.PG fully rescues the dendrite pruning defects seen in lin19EX mutant ddaC neuron clones at 16 hours after puparium formation.

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    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (6)
    References (11)