FB2026_03 , released September 17, 2026
Allele: Dmel\mtdEY04695
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General Information
Symbol
Dmel\mtdEY04695
Species
D. melanogaster
Name
FlyBase ID
FBal0159067
Feature type
allele
Associated gene
Dmel\mtd
Associated Insertion(s)
P{EPgy2}mtdEY04695
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Wang et al., 2012)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}mtdEY04695
Cytology
Description

The insertion is located 200 bp upstream of the start codon of the mtd-RC transcript.

(Wang et al., 2012)

Transcription of mtd-RC is reduced 12-fold in mtdEY04695 flies compared to controls, whereas levels of mtd-RH and all long transcripts (containing the TLDc and LysM domains) are increased in the mutant. mtd-RD transcription is unaffected.

(Wang et al., 2012)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      As measured by H[[2]]O[[2]] ingestion, mtdEY04695 mutants are more resistant to oxidative stress than wild-type.

      In the absence of infection, mtdEY04695 mutants have rates of intestinal stem cell (ISC) division that is at least three time as high as those of control flies. Vibrio cholerae infection results in decreased ISC proliferation, however, compared with wild-type, ISC division rates remain elevated in the mutant.

      There is no significant difference in bacterial load after infection with Vibrio cholerae between control and mutant flies.

      (Wang et al., 2013)

      mtdEY04695 homozygotes show prolonged survival in the face of oral V. cholerae infection compared to wild type. The bacterial burdon of these flies 48 hours after infection is significantly less than controls.

      mtdEY04695/Df(3R)3-4 flies show a susceptibility to V. cholerae infection that is comparable to control flies.

      (Wang et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(3)82FdEY04695
      mtdEY04695
      (Wang et al., 2013, Wang et al., 2012)
      mtdEY0495
      (Wang et al., 2013)
      mtdGOF
      (Wang et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)