FlyBase Allele Report: Dmel\key[c02831]

General Information

Symbol

Dmel\key^c02831

Species

D. melanogaster

Name

FlyBase ID

FBal0159124

Feature type

allele

Associated gene

Dmel\key

Associated Insertion(s)

PBac{PB}key^c02831

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

piggyBac activity

Nature of the Allele

Allele class

Mutagen

piggyBac activity

(Bloomington Drosophila Stock Center, 2004.11.6)

Progenitor genotype

Associated Insertion(s)

PBac{PB}key^c02831

Cytology

Description

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:24,786,643..24,786,643 [-]

(Acheampong et al., 2026, Bloomington Drosophila Stock Center, 2004.11.6)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Bonnay et al., 2013, Bou Aoun et al., 2011)

abnormal immune response | adult stage

(Lee et al., 2016)

abnormal immune response | recessive

(Costa et al., 2009)

fertile

(Bloomington Drosophila Stock Center, 2004.11.6)

viable

(Bloomington Drosophila Stock Center, 2004.11.6)

Phenotype Manifest In

Detailed Description

Statement

Reference

key^c02831/key^c02831 flies have survival rates similar to wild type in response to Sindbis virus infection.

(Lamiable et al., 2016)

key^c02831 adult mutants show increased susceptibility (decreased survival) to infection by both a wild-type and a hemolysin-deficient strain of Serratia marcescens, however the midgut epithelium thinning and subsequent recovery observed in wild-type flies upon infection with occurs normally in key^c02831 homozygous mutant adults.

(Lee et al., 2016)

Homozygous flies die faster than wild-type flies after oral infection with Serratia marcescens DB11.

(Bonnay et al., 2013)

Mutant flies are highly susceptible to infection with E. cloacae (via septic injury).

(Bou Aoun et al., 2011)

Homozygous flies are more sensitive to Cricket Paralysis virus infection (after being injected with the virus) than control flies.

(Costa et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

key^c02831/key^c02831 is a suppressor | partially of short lived phenotype of Diedel¹

(Lamiable et al., 2016)

key^c02831/key^c02831 is a suppressor | partially of abnormal immune response | adult stage phenotype of Diedel¹

(Lamiable et al., 2016)

Other

Statement

Reference

Rel^E20/Rel[+], key^c02831 has abnormal immune response | dominant phenotype

(Costa et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

key[+]/key^c02831 is an enhancer of phenotype of Sindbis\rep^UAS.GFP

(Avadhanula et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Presence of key^c02831/key^c02831 partially suppresses the shorter lifespan in Diedel¹/Diedel¹ flies both in the absence of immune challenge and after Sindbis virus infection.

(Lamiable et al., 2016)

key^c02831/+ ; Rel^E20/+ double heterozygotes are more sensitive to Cricket Paralysis virus infection (after being injected with the virus) than control flies (neither single heterozygote shows increased sensitivity to Cricket Paralysis virus infection).

(Costa et al., 2009)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for key^c02831 in a Scer\GAL4^Act5C.PI Zzzz\rep^{Scer\UAS.T:Avic\GFP} background results in increased Sindbis viral replication.

(Avadhanula et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11044

w¹¹¹⁸; PBac{PB}key^c02831

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Key^c02831

(Acheampong et al., 2026, Tang et al., 2021)

kenny^c02831

(Costa et al., 2009)

kenny[c02831]

(Kawaguchi et al., 2026)

key^C

(Acheampong et al., 2026)

key^c02831

(Lamiable et al., 2016, Lee et al., 2016, Bonnay et al., 2013, Katzenberger et al., 2013, Bou Aoun et al., 2011, Avadhanula et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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