FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SosKG10074
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General Information
Symbol
Dmel\SosKG10074
Species
D. melanogaster
Name
FlyBase ID
FBal0159741
Feature type
allele
Associated gene
Dmel\Sos
Associated Insertion(s)
P{SUPor-P}SosKG10074
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}SosKG10074
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN182Q.UAS
      (Park et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SosKG10074 is a suppressor of eye phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Park et al., 2013)

      SosKG10074 is a suppressor of photoreceptor phenotype of Hsap\ATXN182Q.UAS, Scer\GAL4GMR.PF

      (Park et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      SosKG10074 partially suppresses the external eye phenotype and photoreceptor degeneration seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF. The progressive impairment of motor performance and reduction in lifespan seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4nrv2.PS are also partially rescued.

      (Park et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SosKG10074
      SosLOF
      (Park et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)