FlyBase Allele Report: Dmel\Rheb[44.1]

General Information

Symbol

Dmel\Rheb^44.1

Species

D. melanogaster

Name

FlyBase ID

FBal0159907

Feature type

allele

Associated gene

Dmel\Rheb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Stocker et al., 2003)

Progenitor genotype

Rheb^EP50.084

(Stocker et al., 2003)

Cytology

Description

Imprecise excision of P{EP(loxP.UAS)y⁺.UAS}Rheb^EP50.084, deleting part of the element (0.6Kb remains), without deleting any flanking genomic sequence.

(Stocker et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of type 2 diabetes mellitus

CEA with Rheb^7A1

(Murillo-Maldonado et al., 2011)

CEA with Rheb^2D1

(Murillo-Maldonado et al., 2011)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | adult stage (with Rheb^2G5)

(Stocker et al., 2003)

decreased body size | adult stage (with Rheb^3M2)

(Stocker et al., 2003)

decreased body size | adult stage (with Rheb^7A1)

(Murillo-Maldonado et al., 2011, Stocker et al., 2003)

decreased size | spermatogenesis (with Rheb^7A1)

(Azuma et al., 2021)

female sterile (with Rheb^7A1)

(Stocker et al., 2003)

viable (with Rheb^2G5)

(Stocker et al., 2003)

viable (with Rheb^3M2)

(Stocker et al., 2003)

viable (with Rheb^7A1)

(Murillo-Maldonado et al., 2011, Stocker et al., 2003, Stocker et al., 2003)

Phenotype Manifest In

ommatidium (with Rheb^2G5)

(Stocker et al., 2003)

ommatidium (with Rheb^3M2)

(Stocker et al., 2003)

ommatidium (with Rheb^7A1)

(Stocker et al., 2003)

ovary (with Rheb^7A1)

(Stocker et al., 2003)

spermatocyte (with Rheb^7A1)

(Azuma et al., 2021)

wing (with Rheb^3M2)

(Stocker et al., 2003)

wing (with Rheb^7A1)

(Stocker et al., 2003)

Detailed Description

Statement

Reference

Rheb^44.1/Rheb^7A1 mutant adult flies have a reduced body weight compared to heterozygous controls.

Lipid content is not increased in Rheb^44.1/Rheb^7A1 mutant flies compared to controls. Carbohydrate content is slightly decreased.

Cholinesterase activity is significantly reduced in Rheb^44.1/Rheb^7A1 mutant flies compared to controls.

Rheb^2D1/Rheb^44.1 mutant adult flies have a reduced body weight compared to heterozygous controls.

Lipid content is increased in Rheb^2D1/Rheb^44.1 mutant flies compared to controls. Carbohydrate content is similar to controls.

Homozygous Rheb^2D1/Rheb^44.1 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is significantly reduced in Rheb^2D1/Rheb^44.1 mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

Rheb^2G5/Rheb^44.1 flies weigh significantly less than Rheb^44.1/+ animals, and have significantly smaller ommatidia. Compared to Rheb^44.1/+ animals, Rheb^44.1/Rheb^3M2 and Rheb^44.1/Rheb^7A1 animals are significantly: lighter; have smaller wings and wing cell size; and fewer and smaller ommatidia.

(Stocker et al., 2003)

Rheb^7A1/Rheb^44.1 females have only rudimentary ovaries and are sterile.

(Stocker et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Rheb^44.1

(Azuma et al., 2021)

dRheb^44.1

(Murillo-Maldonado et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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