FlyBase Allele Report: Dmel\Rheb[26.2]

General Information

Symbol

Dmel\Rheb^26.2

Species

D. melanogaster

Name

FlyBase ID

FBal0159911

Feature type

allele

Associated gene

Dmel\Rheb

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size | larval stage (with Rheb^7A1)

(Stocker et al., 2003)

decreased body size | pupal stage (with Rheb^7A1)

(Stocker et al., 2003)

decreased cell size | somatic clone

(Kim et al., 2008)

lethal | pupal stage (with Rheb^7A1)

(Stocker et al., 2003)

lethal - all die before end of pupal stage (with Rheb^3M2)

(Stocker et al., 2003)

partially lethal - majority die | larval stage (with Rheb^7A1)

(Stocker et al., 2003)

some die during pupal stage (with Rheb^3M2)

(Stocker et al., 2003)

Phenotype Manifest In

embryonic/larval salivary gland (with Rheb^3M2)

(Stocker et al., 2003)

imaginal disc (with Rheb^3M2)

(Stocker et al., 2003)

Detailed Description

Statement

Reference

Homozygous clones in the fat body show a reduction in relative cell area compared to controls.

(Kim et al., 2008)

Rheb^26.2/Rheb^7A1 larvae and pupae are much smaller than wild-type. The smallest die as larvae, while the rest arrest development and then die during the pupal stages. Rheb^26.2/Rheb^3M2 animals die as pupae. The imaginal discs from larvae of this genotype are smaller than wild-type, roughly in proportion with their small body size. The salivary glands of these animals are even more severely reduced in size.

(Stocker et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Rheb^26.2 has decreased cell size | somatic clone phenotype, non-suppressible by Scer\GAL4^unspecified/RagA-B^Q61L.UAS

(Kim et al., 2008)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The decrease in relative cell area compared to controls that is seen in Rheb^26.2 clones in the fat body is not rescued by expression of RagA^{Q61L.Scer\UAS} under the control of Scer\GAL4^unspecified.

(Kim et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rheb^26.2

(Kim et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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