FlyBase Allele Report: Dmel\M6[EY07032]

General Information

Symbol

Dmel\M6^EY07032

Species

D. melanogaster

Name

FlyBase ID

FBal0160210

Feature type

allele

Associated gene

Dmel\M6

Associated Insertion(s)

P{EPgy2}M6^EY07032

Carried in Construct

Also Known As

M6⁰¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Gregor et al., 2014, Zappia et al., 2012, Zappia et al., 2011)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}M6^EY07032

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:21,507,927..21,507,927 [-]

(Zappia et al., 2012, Zappia et al., 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intellectual disability

CEA

(Gregor et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Kaltenbach et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

egg

(Zappia et al., 2011)

eye

(Zappia et al., 2012)

eye (with M6^MB02608)

(Zappia et al., 2012)

interommatidial bristle

(Zappia et al., 2012)

interommatidial bristle (with M6^MB02608)

(Zappia et al., 2012)

ommatidium

(Zappia et al., 2012)

ommatidium (with M6^MB02608)

(Zappia et al., 2012)

Detailed Description

Statement

Reference

M6^EY07032 mutants do not exhibit defects in neuromuscular junctions or locomotion, but do exhibit defective long term memory.

(Gregor et al., 2014)

The maximal lifespan in homozygous M6^EY07032 mutant males is similar to controls. However, the median lifespan is significantly reduced compared to both heterozygous controls and wild type.

Homozygous M6^EY07032 mutant males exhibit a mild rough eye phenotype, as well as a disorganised ommatidium array, defects in ommatidium shape and/or ommatidium fusion and defective or missing interommatidial bristles.

M6^EY07032/M6^MB02608 mutant males exhibit a mild rough eye phenotype, as well as a disorganised ommatidium array, defects in ommatidium shape and/or ommatidium fusion and defective or missing interommatidial bristles. Approximately 20% of M6^EY07032/M6^MB02608 transheterozygote eyes exhibit an excessive interommatidial space.

Young homozygous M6^EY07032 mutant males exhibit a significantly defective phototactic response compared to controls. Locomotor activity in general appears to be unaffected.

Young transheterozygous M6^EY07032/M6^MB02608 mutant males exhibit a significantly defective phototactic response compared to controls. Locomotor activity in general appears to be unaffected.

(Zappia et al., 2012)

Homozygous females lay a significantly reduced number of eggs compared to controls. Eggs laid by these females collapse soon after deposition, with almost 100% being collapsed within 20 minutes of laying. The mutant eggs are permeable to neutral red, in contrast to wild type.

Homozygous ovarioles do not show morphological defects at any stages of oogenesis.

(Zappia et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

M6^EY07032, Scer\GAL4^GMR.PU is an enhancer of visible phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

M6^EY07032, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Kaltenbach et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

16780

y¹ w^67c23; P{EPgy2}M6^EY07032

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EY07032

(Kaltenbach et al., 2007)

M6⁰¹

(Zappia et al., 2012, Zappia et al., 2011)

M6^EY07032

(Gregor et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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