FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LarC1929S.UAS
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General Information
Symbol
Dmel\LarC1929S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0160246
Feature type
allele
Associated gene
Dmel\Lar
Associated Insertion(s)
Carried in Construct
P{UAS-Lar.C1929S}
Key Links
Transgenic product class
missense_variant
(Krueger et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Krueger et al., 2003)
Mutagen
in vitro construct
(Krueger et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Lar.C1929S}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Lar (carries the amino acid replacement C1929S).

(Krueger et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Lar
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Much higher frequency bypass phenotype when expressed in Lar13.2/Lar5.5 than for Lar13.2/Lar5.5 alone. This phenotype is not seen with LarCSX2.Scer\UAS. LarC1929S.Scer\UAS causes no detectable phenotype when expressed in an otherwise normal background.

      (Krueger et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/LarC1929S.UAS rescues LarC12/Lar2127

      (Hofmeyer and Treisman, 2009)

      Scer\GAL4elav-C155/LarC1929S.UAS rescues Lar2127

      (Prakash et al., 2009)
      Partially rescues

      Scer\GAL4elav-C155/LarC1929S.UAS partially rescues Lar5.5/Lar13.2

      (Krueger et al., 2003)

      Scer\GAL4elav-C155/LarC1929S.UAS partially rescues Lar5.5/Lar5.2

      (Krueger et al., 2003)
      Comments

      Expression of LarC1929S.Scer\UAS under the control of Scer\GAL4elav-C155 in LarC12/Lar2127 mutant eye discs rescues axon mistargeting.

      (Hofmeyer and Treisman, 2009)

      Expression of LarC1929S.Scer\UAS under the control of Scer\GAL4elav-C155 completely rescues the aberrant axon extension in Lar2127 mutant photoreceptor cells.

      (Prakash et al., 2009)

      Partial rescue statement based on rescue of lethality.

      (Krueger et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LarC1929S.Scer\UAS
      LarC1929S.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)