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General Information
Symbol
Dmel\jusf04904
Species
D. melanogaster
Name
FlyBase ID
FBal0162251
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
PBac{WH}jusf04904
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

jusf04904 homozygotes, jusiso7.8/jusf04904 transheterozygotes and jusf04904/Df(3R)BSC501 transheterozygotes show an abnormal and fully penetrant paralysis phenotype upon exposure to 14[o]C or 10[o]C temperatures, which is associated with a significant increase in recovery time from paralysis upon shift to room temperature, as compared to wild-type controls; jusf04904 heterozygotes also show an abnormal and highly penetrant paralysis phenotype upon exposure to 10[o]C, but not 14[o]C, temperatures, despite of an apparently normal recovery time from paralysis upon shift to room temperature, as compared to wild-type controls.

jusf04904 as well as jusiso7.8/jusf04904 and jusf04904/Df(3R)BSC501 flies are bang sensitive with jusiso7.8/jusf04904 displaying the shortest and jusf04904/Df(3R)BSC501 the longest recovery time.

High frequency electrical stimulation of jusf04904 mutant flies induces primary seizure occuring immediately after the stimulus followed by a secondary 'recovery' seizure around 70 sec later - this is significantly longer than in the jusiso7.8 mutants where the average interval between seizures is only about 30 sec, the seizure stimulus threshold however is comparable between the mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

The bang-sensitivity phenotype of jusiso7.8 mutants cannot be complemented by combination with jusf04904.

The median recovery time after mechanical shock-induced paralysis of jusiso7.8/jusf04904 flies is significantly shortened by combination with a single copy of jusT:Scer\TY1,T:Avic\GFP-SF,T:SV5\V5,T:Zzzz\BLRP,T:Zzzz\FLAG.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG14509f04904
Name Synonyms
Secondary FlyBase IDs
    References (4)