FB2026_02 , released June 18, 2026
Allele: Dmel\MetE1
Open Close
General Information
Symbol
Dmel\MetE1
Species
D. melanogaster
Name
FlyBase ID
FBal0176019
Feature type
allele
Associated gene
Dmel\Met
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: L157S.

    (Wilson et al., 2006)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:11,617,337..11,617,337 [+]
    Nucleotide change:

    T11617337C

    Amino acid change:

    L157S | Met-PA; L157S | Met-PB

    Reported amino acid change:

    L157S

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Wilson et al., 2006)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Weak allele.

        (Wilson et al., 2006)

        Homozygotes show increased resistance to methoprene compared to controls. At sublethal doses, 18% of surviving females have bristle defects and 14% of surviving males have abnormal genitalia.

        (Wilson et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        MetE1/MetE1 is a non-enhancer of ovary phenotype of br1

        (Wilson et al., 2006)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        br1/Y, Rst(1)JHE1/Y hemizygotes show good levels of survival.

        (Wilson et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        MetE1
        (Wilson et al., 2006, Wilson et al., 2006, Flatt and Kawecki, 2004)
        Rst(1)JHE1
        Name Synonyms
        Secondary FlyBase IDs
          References (3)