FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\wntDKO1
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General Information
Symbol
Dmel\wntDKO1
Species
D. melanogaster
Name
FlyBase ID
FBal0177123
Feature type
allele
Associated gene
Dmel\wntD
Associated Insertion(s)
TI{TI}wntDKO1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
I-SceI
(Gordon et al., 2005)
recombination
(Gordon et al., 2005)
gene targeting by homologous recombination
(Gordon et al., 2005)
Progenitor genotype
Associated Insertion(s)
TI{TI}wntDKO1
Cytology
Description

A w+* marker has been inserted into the middle of the wntD gene, disrupting the open reading frame.

(Gordon et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wntDKO1 mutant embryos (lacking maternal and zygotic wntD function) have an increased average number of mislocalised primordial germ cells compared to wild type at stages 14-16. There is also an increase in the proportion of embryos with more than 2 mislocalised cells in the mutants.

      (McElwain et al., 2011)

      When mutant animals are infected with L.monocytogenes, mutant animals exhibit increased mortality.

      (Gordon et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      wntDKO1 has abnormal immune response phenotype, suppressible | partially by dl[+]/dl4

      (Gordon et al., 2005)

      wntDKO1 has abnormal immune response phenotype, suppressible by dl4/dl1

      (Gordon et al., 2005)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DWnt8KO1
      (Takagi et al., 2025)
      wntDKO1
      (Rahimi et al., 2016, McElwain et al., 2011, Gordon et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)