FB2026_03 , released September 17, 2026
Allele: Dmel\tjz4735
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General Information
Symbol
Dmel\tjz4735
Species
D. melanogaster
Name
FlyBase ID
FBal0177449
Feature type
allele
Associated gene
Dmel\tj
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Levine et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q459term.

(Li et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,466,136..19,466,136 [+]
Nucleotide change:

C19466136T

Amino acid change:

Q461term | tj-PB; Q461term | tj-PC

Reported amino acid change:

Q459term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larval cap cell tjz4735/tjz4735 mutant clones in the female germline stem cell niche (cap and/or terminal filament cells) exhibit cap cells being transformed to a terminal filament cell-like shape and position, independent of whether the neighboring terminal filament cell is a mutant or a control cell.

      tjPL3/tjz4735 females exhibit morphology changes in cap cells, with the cap cells forming a terminal filament-like stalk. Prepupal terminal filaments in tjPL3/tjz4735 mutants are also longer than in wild type ovaries, due to defects in cap cell specification.

      (Panchal et al., 2017)

      tjz4735 mutants exhibit severe gonadal defects, but are viable and display no other gross morphological abnormalities. tjz4735 mutant ovaries are small, disorganised, and lack mature germ cells, Germline cells are absent in approximately 26-27% of 1-2 day old tjz4735 mutant ovaries. Within 1-2 weeks, the number of ovaries without germline cells doubles to approximately 44%.

      (Li et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tjz3434

      (Li et al., 2003)

      tjz1949

      (Li et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Z2-4735
      (Levine et al., 2007)
      tjz4735
      (Panchal et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)