FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PacsZ1610
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General Information
Symbol
Dmel\PacsZ1610
Species
D. melanogaster
Name
FlyBase ID
FBal0178020
Feature type
allele
Associated gene
Dmel\Pacs
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Giansanti et al., 2004)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      contractile ring & meiotic cell cycle | male

      (Giansanti et al., 2004)

      contractile ring & meiotic cell cycle | male (with Df(3R)mbc-R1)

      (Giansanti et al., 2004)

      Nebenkern

      (Giansanti et al., 2004)

      Nebenkern (with Df(3R)mbc-R1)

      (Giansanti et al., 2004)

      spermatid & nucleus | supernumerary

      (Giansanti et al., 2004)

      spermatid & nucleus | supernumerary (with Df(3R)mbc-R1)

      (Giansanti et al., 2004)

      spindle & meiotic cell cycle | male

      (Giansanti et al., 2004)

      spindle & meiotic cell cycle | male (with Df(3R)mbc-R1)

      (Giansanti et al., 2004)
      Detailed Description
      Statement
      Reference

      A significant proportion of sgoZ1610 mutant spermatids have one large nebenkern with two nuclei of normal size, indicating failure of cytokinesis in one of the meiotic divisions. Further, a smaller amount of spermatids have four nuclei and a large nebenkern, indicating a cytokinetic failure in both meiotic divisions. A small proportion of spermatids have three nuclei, which may be due to failure of cytokinesis in the first meiotic division, followed by budding off of only one daughter cell in the second meiotic division. sgoZ1610/Df(3R)mbc-R1 mutant spermatids exhibit the two and four nuclei phenotypes, but never have three nuclei. Spermatocytes of sgoZ1610 mutants lack an organized central spindle and an F-actin ring throughout ana-telophase. The equatorial anillin band is present but fails to constrict properly. sgoZ1610/Df(3R)mbc-R1 mutants have the same phenotype.

      (Giansanti et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PacsZ1610
      sgoZ1610
      sgoz1610
      (Frappaolo et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)