FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sar128
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General Information
Symbol
Dmel\Sar128
Species
D. melanogaster
Name
FlyBase ID
FBal0178125
Feature type
allele
Associated gene
Dmel\Sar1
Associated Insertion(s)
Carried in Construct
Also Known As
sar1EP3575Δ28
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Zhu et al., 2005)
Mutagen
Delta2-3 transposase
(Zhu et al., 2005)
Progenitor genotype
Sar1EP3575
(Zhu et al., 2005, Zhu et al., 2005)
Cytology
Description

Imprecise excision of the P{EP}sar1EP3575 insertion, resulting in a deletion of 2114bp. The deletion affects four exons of sar1, including the first coding exon shared by all transcripts.

(Zhu et al., 2005)

The left breakpoint of the deletion (twenty first deleted nucleotides) is TTATGATTAA AAAAAACTGA, the right breakpoint of the deletion (twenty last deleted nucleotide) is ACCCATACAG CCAGTGCGTC (sequence is given in the same orientation as the coding strand of the gene).

(Zhu et al., 2005)

Imprecise excision of the P{EP} element, resulting in a deletion of part of sar1.

(Zhu et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:22,356,707..22,358,821 [+]
Comment:

Deletion associated with the imprecise excision of the P{EP}Sar1EP3575 insertion.

(Zhu et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant larvae have a thin and pale cuticle, though the three histologically distinct layers of the cuticle are established normally. Apical undulae and taenidial folds are normal. However, the ER of epidermal cells is abnormally bloated and spherical.

      (Norum et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Sar1EP3575

      (Zhu et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      #28
      (Zhu et al., 2005, Zhu et al., 2005)
      Sar128
      sar1#28
      (Norum et al., 2010)
      sar128
      sar1EP3575Δ28
      (Massarwa et al., 2009, Jayaram et al., 2008)
      sar1Δ28
      (Jayaram et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)