FlyBase Allele Report: Dmel\Pgant3[c01318]

General Information

Symbol

Dmel\Pgant3^c01318

Species

D. melanogaster

Name

FlyBase ID

FBal0178456

Feature type

allele

Associated gene

Dmel\Pgant3

Associated Insertion(s)

PBac{PB}Pgant3^c01318

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

piggyBac activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Zhang et al., 2008)

Mutagen

piggyBac activity

(Gene Disruption Project members and Exelixis, 2005)

Progenitor genotype

Associated Insertion(s)

PBac{PB}Pgant3^c01318

Cytology

Description

Insertion in the fourth intron.

(Zhang et al., 2008)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:7,059,777..7,059,810 [+]

(Zhang et al., 2008, Gene Disruption Project members and Exelixis, 2005)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with Df(2R)Exel6283)

(Zhang et al., 2008)

visible (with Pgant3^m1)

(Zhang et al., 2010)

visible (with Pgant3^m2)

(Zhang et al., 2010)

visible | recessive

(Zhang et al., 2010, Zhang et al., 2008)

Phenotype Manifest In

wing blade

(Zhang et al., 2010, Zhang et al., 2008)

wing blade (with Df(2R)Exel6283)

(Zhang et al., 2008)

wing blade (with Pgant3^m1)

(Zhang et al., 2010)

wing blade (with Pgant3^m2)

(Zhang et al., 2010)

wing disc

(Zhang et al., 2008)

Detailed Description

Statement

Reference

Homozygous, pgant3^m1/pgant3^c01318 and pgant3^m2/pgant3^c01318 flies have a blistered wing phenotype.

(Zhang et al., 2010)

Most homozygotes survive to adulthood, although there is some reduction in viability relative to heterozygotes.

The wings of homozygous adults develop blisters as they unfold, which later collapse into crumpled areas around the wing blade. The extent of blistering varies, with some wings having small blisters and others showing blistering across the entire wing blade.

pgant3^c01318/Df(2R)Exel6283 flies have a wing blistering phenotype.

pgant3^c01318/pgant3^c01318-rev7 flies do not have a wing blistering phenotype.

Mutant wing discs are decreased in thickness relative to wild type.

(Zhang et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Pgant3^c01318 has visible | recessive phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Pgant35A^UAS.cTa

(Zhang et al., 2008)

Other

Statement

Reference

pgant3[+]/Pgant3^c01318, Tig^A1 has visible | dominant | cold sensitive phenotype

(Zhang et al., 2008)

pgant3[+]/Pgant3^c01318, Tig^x has visible | dominant | cold sensitive phenotype

(Zhang et al., 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Pgant3^c01318 has wing blade phenotype, non-suppressible by Scer\GAL4^αTub84B.PL/Pgant35A^UAS.cTa

(Zhang et al., 2008)

Other

Statement

Reference

pgant3[+]/Pgant3^c01318, Tig^A1 has wing blade | cold sensitive phenotype

(Zhang et al., 2008)

pgant3[+]/Pgant3^c01318, Tig^x has wing blade | cold sensitive phenotype

(Zhang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pgant35A^Scer\UAS.cTa under the control of Scer\GAL4^αTub84B.PL does not rescue the wing blistering phenotype of pgant3^c01318 homozygotes.

8% of pgant3^c01318/Tig^x and 6% of pgant3^c01318/Tig^A1 double heterozygotes show wing blistering at 18[o]C.

(Zhang et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Pgant3^c01318 is rescued by Pgant3^UAS.cZa

(Zhang et al., 2008)

Comments

pgant3^Scer\UAS.cZa rescues the wing blistering phenotype of pgant3^c01318 homozygotes, even in the absence of a Scer\GAL4 driver.

(Zhang et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

85948

w¹¹¹⁸; PBac{PB}Pgant3^c01318/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pgant3^c01318

pgant3^c01318

(Zhang et al., 2010, Zhang et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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