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General Information
Symbol
Dmel\par-1UAS.ΔSP.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0178516
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The par-1 Spacer domain has been deleted.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The oocyte nucleus is mislocalised to the centre of the oocyte in 96% of egg chambers of females expressing par-1Scer\UAS.ΔSP.T:Avic\GFP under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

When par-1Scer\UAS.ΔSP.T:Avic\GFP is expressed in par-1W3 mutant clones, stable wild-type microtubule network is seen. When par-1Scer\UAS.ΔSP.T:Avic\GFP is expressed in par-1W3 cells (driven by Scer\GAL4αTub84B.PL) follicel cell formation is rescued, however round cells are seen that protrude from some portions of an otherwise normal cuboidal epithelium. Multi-layering of the FE is evident after stage 6, which correlates with a failure to differentiate a columnar FE over the oocyte, and in severe cases results in an egg-chamber degeneration around stages 8 and 9.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The penetrance of the oocyte mislocalisation phenotype seen in egg chambers of females expressing par-1Scer\UAS.ΔSP.T:Avic\GFP under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 is reduced by co-expression of tauScer\UAS.P\T.T:Avic\GFP-m6 (from 96% to 33%).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of par-1Scer\UAS.ΔSP.T:Avic\GFP in Scer\GAL4αTub84B.PL follicle epithelial (FE) cells rescues the formation of the FE, though the morphology and development of these cells is abnormal.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
par-1Scer\UAS.ΔSP.T:Avic\GFP
par-1UAS.ΔSP.GFP
Name Synonyms
Secondary FlyBase IDs
    References (3)