FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htlK443A.λ.UAS.Tag:HA
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General Information
Symbol
Dmel\htlK443A.λ.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0179440
Feature type
allele
Associated gene
Dmel\htl
Associated Insertion(s)
Carried in Construct
P{UAS-htl.λ.K443A}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Wilson et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-htl.λ.K443A}
Cytology
Description

UAS regulatory sequences drive expression of a kinase-dead form of "activated" htl, which consists of the transmembrane and cytoplasmic domains of htl carrying the K443A mutation to abolish kinase function, the dimerization domain of the bacteriophage λ cI repressor (included to induce constitutive dimerization of the encoded protein) and two copies of the Tag:HA tag.

(Wilson et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
htl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4twi.PG/htlK443A.λ.UAS.Tag:HA fails to rescue htlAB42

      (Wilson et al., 2005)
      Comments

      Expression of htlK443A.Scer\UAS.T:λ\cI-DD,T:Ivir\HA1 under the control of Scer\GAL4twi.PG is unable to rescue mesodermal spreading in htlAB42 mutant embryos.

      (Wilson et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      htlK443A.Scer\UAS.T:λ\cI-DD,T:Ivir\HA1
      htlK443A.λ.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)