FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\guse00456
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General Information
Symbol
Dmel\guse00456
Species
D. melanogaster
Name
FlyBase ID
FBal0179566
Feature type
allele
Associated gene
Dmel\gus
Associated Insertion(s)
PBac{RB}guse00456
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

hypermorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypermorphic allele - genetic evidence

(Kugler et al., 2010)

hypomorphic allele - molecular evidence

(Kugler et al., 2010)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{RB}guse00456
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      guse00456/Df(2R)nap1 flies display abnormal wing morphology, including blistering, formation of ectopic vein material, and loss of material at the margin. These phenotypes occur at low penetrance.

      Embryos laid by homozygous guse00456 mutant mothers hatch only rarely and most viable embryos are produced by young females. However, guse00456 in trans to stronger alleles (Df(2R)nap1 or gusf07073), this allele has little effect on embryonic viability.

      (Kugler et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      guse00456
      (Kugler et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)