FlyBase Allele Report: Dmel\by[33c]

General Information

Symbol

Dmel\by^33c

Species

D. melanogaster

Name

FlyBase ID

FBal0180605

Feature type

allele

Associated gene

Dmel\by

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Torgler et al., 2004)

Progenitor genotype

by^P

(Torgler et al., 2004)

Cytology

Description

Imprecise excision of P{}by^P has removed the by transcriptional start and the majority of the coding region.

(Torgler et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by Ras85D^V12.UAS

(Martínez-Abarca Millán et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | larval stage

(Martínez-Abarca Millán et al., 2023)

viable

(Torgler et al., 2004)

visible | adult stage

(Martínez-Abarca Millán et al., 2023)

Phenotype Manifest In

wing

(Martínez-Abarca Millán et al., 2023)

wing | adult stage A2

(Torgler et al., 2004)

wing | adult stage A3

(Torgler et al., 2004)

wing disc

(Martínez-Abarca Millán et al., 2023)

Detailed Description

Statement

Reference

Follicle cell stress fibres in by^33c mutants seem normal.

(Delon and Brown, 2009)

The wings of by^33c homozygous flies have a large distal blister. These blisters are not apparent upon eclosion, but appear as the files stroke their wings as they unfold. The phenotype is suppressed if the flies legs are glued to a slide after eclosion to prevent them from stroking their wings.

(Torgler et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

by^33c is an enhancer of hyperplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

by^33c is an enhancer of abnormal cell shape | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

by^33c is an enhancer of increased cell growth rate | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

by^33c is an enhancer of increased cell death | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

NOT Enhancer of

Statement

Reference

by^33c is a non-enhancer of abnormal cell migration | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Suppressor of

Statement

Reference

by^33c is a suppressor of decreased occurrence of cell division | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

NOT Suppressor of

Statement

Reference

by^33c is a non-suppressor of abnormal cell migration | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Other

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has partially lethal - majority die phenotype

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has visible | adult stage phenotype

(Martínez-Abarca Millán et al., 2023)

Phenotype Manifest In

Enhancer of

Statement

Reference

by^33c is an enhancer of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^ap-md544

(Martínez-Abarca Millán et al., 2023)

Other

Statement

Reference

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has wing phenotype

(Martínez-Abarca Millán et al., 2023)

PVRAP^HMJ23233, Scer\GAL4^ap-md544, by^33c has scutum phenotype

(Martínez-Abarca Millán et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

by^33c is rescued by by^GFP

(Torgler et al., 2004)

Partially rescued by

by^33c is partially rescued by by^R483E.GFP

(Torgler et al., 2004)

by^33c is partially rescued by by^PTB.UAS.GFP/Scer\GAL4^CY2

(Torgler et al., 2004)

Not rescued by

by^33c is not rescued by Scer\GAL4^CY2/by^{SH2PTB.UAS.GFP}

(Torgler et al., 2004)

Comments

by^{Scer\UAS.T:Avic\GFP}; Scer\GAL4^CY2 partially rescues the blistered wing phenotype of by^33c homozygotes (22.5% fully rescued; 59.5% partially rescued; 18% not rescued (n = 160).) by^{R483E.t11.T:Avic\GFP} only very weakly rescues the blistered wing phenotype of by^33c flies: Depending on the insertion line, 67%-100% of show no rescue, 0%-14% show a partial rescue, and 0-19% show complete rescue (5 lines tested, N = 52). by^{SH2PTB.Scer\UAS.T:Avic\GFP}; Scer\GAL4^CY2 does not rescue the blistered wing phenotype of by^33c homozygotes.