FB2026_02 , released June 18, 2026
Allele: Dmel\Top2f05145
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General Information
Symbol
Dmel\Top2f05145
Species
D. melanogaster
Name
FlyBase ID
FBal0181194
Feature type
allele
Associated gene
Dmel\Top2
Associated Insertion(s)
PBac{WH}Top2f05145
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Top2f05145
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Top2f05145 homozygous mutants are larval lethal. They exhibit their highest mortality rate during the second instar stage with fewer than 5% of individuals escaping into the third instar larval stage. These escapers are smaller than wild-type larvae and have less developed salivary glands and central nervous systems while displaying extremely reduced to completely absent imaginal tissue.

      Homozygous Top2f05145 mutants progress normally through embryogenesis, but once hatched these animals show a 2-3 day delay in development when compared to wild-type larvae reared under identical conditions.

      (Ramos et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Top2f05145
      Top2f
      (Ramos et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)