FB2026_02 , released June 18, 2026
Allele: Dmel\Or43b1
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General Information
Symbol
Dmel\Or43b1
Species
D. melanogaster
Name
FlyBase ID
FBal0182427
Feature type
allele
Associated gene
Dmel\Or43b
Associated Insertion(s)
TI{TI}Or43b1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Elmore et al., 2003)
FLPase
(Elmore et al., 2003)
gene targeting by homologous recombination
(Elmore et al., 2003)
Progenitor genotype
Associated Insertion(s)
TI{TI}Or43b1
Cytology
Description

Duplication of Or43b with one copy containing one introduced stop codon and the other copy containing two introduced stop codons. A w+mW.hs marker gene and a single FRT site are present between the two copies of Or43b.

(Elmore et al., 2003)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Odor-evoked depolarizations in Or43b1 mutant VM2 projection neurons are indistinguishable from depolarizations in wid-type. Spontaneous activity in these projection neurons is also unaffected by the mutation.

      (Kazama et al., 2011)

      VM2 projection neurons (PNs) have normal dendrite morphology in mutant flies. The VM2 PNs in the mutant flies (these projection neurons are postsynaptic to "silent" ORNs due to the mutation in Or43b) show reduced spontaneous electrophysiological activity compared to wild type.

      (Olsen et al., 2007)

      Or43b1 flies have no gross behavioral or morphological phenotypes. The ab8A neuron in Or43b1 mutants is not activated in response to fifty-five odorants that activate these neurons in wild-type flies. However, mutant neurons still show spontaneous activity. No significant difference in chemosensory behavior can be detected between Or43b2 mutant and wild-type flies.

      (Elmore et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Or43b
      (Lieber et al., 2011)
      Or43b1
      (Kazama et al., 2011, Olsen et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)