FB2026_02 , released June 18, 2026
Allele: Mmus\Med29UASp.cSa
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General Information
Symbol
Mmus\Med29UASp.cSa
Species
M. musculus
Name
Saccharomyces cerevisiae UAS construct a of Siegal
FlyBase ID
FBal0182670
Feature type
allele
Associated gene
Mmus\Med29
Associated Insertion(s)
Carried in Construct
P{UASp-Mmus\Med29.S}
Transgenic product class
wild_type
(Siegal and Baker, 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Siegal and Baker, 2005)
Mutagen
in vitro construct
(Siegal and Baker, 2005)
Progenitor genotype
Carried in construct
P{UASp-Mmus\Med29.S}
Cytology
Description

Expression of Mmus\Med29 is governed by UASp regulatory sequences.

(Siegal and Baker, 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Mmus\Med29
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expressing Mmus\IxlScer\UAS.P\T.cSa in the fly, under the control of Scer\GAL4αTub84B.PL does not rescue the ix3/Df(2R)en-B phenotype. The pigmentation of abdominal tergite 6 was male-like, the anal plates were shifted laterally, the vaginal teeth were reduced in number and not present in rows and the last transverse row bristles, which form the sex combs in the male, were darker, thicker, and rotated upwards, as in the male. Expressing Mmus\IxlScer\UAS.P\T.cSa under the control of Scer\GAL4αTub84B.PL in heterozygous ix3 females yields a strong intersexual transformation. Indeed females heterzygous for endogenous ix and expressing Mmus\IxlScer\UAS.P\T.cSa are indistinguishable from females homozygous ix3 mutant and expressing Mmus\IxlScer\UAS.P\T.cSa, suggesting that Mmus\IxlScer\UAS.P\T.cSa acts in a dominant-negative manner.

      (Siegal and Baker, 2005)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mmus\IxlScer\UAS.P\T.cSa
      Mmus\Med29Scer\UAS.P\T.cSa
      Mmus\Med29UASp.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Siegal
      (Siegal and Baker, 2005)
      Secondary FlyBase IDs
        References (1)