FB2026_02 , released June 18, 2026
Allele: Dmel\GluRIIAhypo.tQa
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General Information
Symbol
Dmel\GluRIIAhypo.tQa
Species
D. melanogaster
Name
FlyBase ID
FBal0183419
Feature type
allele
Associated gene
Dmel\GluRIIA
Associated Insertion(s)
Carried in Construct
P{GluRIIA.hypo}
Also Known As
GluRIIAhypo
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Qin et al., 2005)
Progenitor genotype
Carried in construct
P{GluRIIA.hypo}
Cytology
Description

A genomic fragment that encompasses the promoter region and the whole open reading frame of GluRIIA but lacks most of the 3' UTR.

(Qin et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
GluRIIA
Encoded product / tool
GluRIIA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mature larvae expressing GluRIIAhypo.tQa in a Df(2L)cl-h4/Df(2L)SP22 background show a reduction in both the number of synapses per neuromuscular junction and the number of boutons in each synapse. In addition, some boutons appear abnormally round. Severe defects in membrane organization in the synapses at the neuromuscular junction are seen.

      (Schmid et al., 2006)

      In a GluRIIB null background (Df(2L)SP22/Df(2L)cl-h4), GluRIIAhypo.Scer\UAS larvae show clear signs of paralysis. Spontaneous mEJCs are below the detection limit, indicating an extreme drop in postsynaptic glutamate receptor function.

      (Qin et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      GluRIIAhypo.Scer\UAS
      GluRIIAhypo.tQa
      GluRIIAhypo
      (Qin et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)