FlyBase Allele Report: Dmel\Fak[5-SZ-3124]

General Information

Symbol

Dmel\Fak^5-SZ-3124

Species

D. melanogaster

Name

FlyBase ID

FBal0183606

Feature type

allele

Associated gene

Dmel\Fak

Associated Insertion(s)

P{RS5}Fak^5-SZ-3124

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{RS5}Fak^5-SZ-3124

Cytology

Description

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,436,970..19,436,970

(Grabbe et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.UAS

(Macagno et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Fak^5-SZ-3124 exacerbates the phenotypes seen in Ret^{MEN2A.Scer\UAS} when heterozygous with Fak^CG1.

(Macagno et al., 2014)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable (with Fak^CG1)

(Macagno et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Fak^CG1/Fak^5-SZ-3124 is an enhancer of partially lethal - majority die phenotype of Ret^MEN2A.UAS, Scer\GAL4^dpp.PU

(Macagno et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Fak^CG1/Fak^5-SZ-3124 is an enhancer of wing disc phenotype of Ret^MEN2A.UAS, Scer\GAL4^dpp.PU

(Macagno et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Fak^CG1/Fak^5-SZ-3124 enhances the partial lethality and wing disc defects seen when Ret^{MEN2A.Scer\UAS} is expressed under the control of Scer\GAL4^dpp.PU. The proportion of surviving flies rises from 46% to 92%.

(Macagno et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

125903

w¹¹¹⁸; P{RS5}Fak^5-SZ-3124

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Fak56D^5-SZ-3124

Fak^5-SZ-3124

dFAK^5-SZ-3124

(Macagno et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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