FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Irbp18f05006
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General Information
Symbol
Dmel\Irbp18f05006
Species
D. melanogaster
Name
FlyBase ID
FBal0185260
Feature type
allele
Associated gene
Dmel\Irbp18
Associated Insertion(s)
PBac{WH}Irbp18f05006
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Irbp18f05006
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Irbp18f05006 homozygosity increases the severity of the somatic dysgenesis phenotype at low (survival permissive) temperatures in flies carrying the Birm2 chromosome (a second chromosome with 17 non-autonomous P-elements) together with a source of transposase. Irbp18f05006 homozygous mutants also display reduced survival rate upon exposure to ionizing radiation or a DNA-damaging agent.

      (Francis et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Irbp18f05006 is rescued by Irbp18+t1.5

      (Francis et al., 2016)
      Comments

      The increased sensitivity of Irbp18f05006 homozygotes to ionizing radiation or DNA-damaging agents resulting in reduced survival rates compared to the controls can be rescued by combination with Irbp18+t1.5.

      (Francis et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG6272WHf05006
      (Francis et al., 2016)
      CG6272f05006
      IRBP18WHf05006
      (Francis et al., 2016)
      Irbp18f05006
      irbp18f05006
      (Blanco et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)