85% of homozygous Dmtn^e01970 escapers exhibit wing expansion defects. No defects are seen in heterozygous controls.

Most homozygous Dmtn^e01970 mutant flies die during metamorphosis and adult escapers die within a few days. Heterozygotes have a normal lifespan. The optic lobes of homozygous but not heterozygous Dmtn^e01970 flies are severely reduced in size, and missing much of the medulla neuropil.

10 day old Dmtn^e01970 mutant flies in which Dmtn expression has been rescued in glia (through expression of Dmtn^Scer\UAS.cHa under the control of Scer\GAL4^repo) show evidence of neurodegeneration in the form of vacuoles. These vacuoles are rarely seen in 10 day old flies expressing Dmtn^Scer\UAS.cHa in neurons under the control of Scer\GAL4^elav-C155, or expressing Dmtn^Scer\UAS.cHa in both neurons and glia. Vacuoles are not seen in any of the rescued flies at one day old.

Dmtn^e01970 mutant flies expressing Dmtn^Scer\UAS.cHa in glia under the control of Scer\GAL4^repo have a severely reduced lifespan compared to those expressing Dmtn^Scer\UAS.cHa in neurons under the control of Scer\GAL4^elav-C155, or in both neurons or glia.