FB2026_02 , released June 18, 2026
Allele: Dmel\veloe01260
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General Information
Symbol
Dmel\veloe01260
Species
D. melanogaster
Name
FlyBase ID
FBal0187913
Feature type
allele
Associated gene
Dmel\velo
Associated Insertion(s)
PBac{RB}veloe01260
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{RB}veloe01260
Cytology
Description

Insertion in the fifth intron of the long transcript of velo, 33 bp upstream from the second exon in the first intron of the short velo transcript.

(Berdnik et al., 2012)
Allele components
Component
Use(s)
Inserted element
PBac{RB}
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      veloe01260 mutants display projection neuron dendrite targeting defects.

      veloe01260 mutant neuroblast clones exhibit several defects. First, the number of neurons is reduced from an average of 35 ad projection neurons in wild-type to 5 neurons in veloe01260 mutant clones. Second, the overall dendritic mass is reduced and disorganised Third, dendrites aberrantly innervate the wrong glomeruli within the antennal lobe, or ectopically project outside the antennal lobe.

      veloe01260 mutant DL1 projection neurons exhibit defects in axon morphology. Axons extend as wild-type and always reach the end of the lateral horn, but only form 0-2 collaterals in the mushroom body calyx, and often have a missing or shorter dorsal branch in the lateral horn. These axonal phenotypes are independent of the phenotypic class of dendrite mistargeting.

      In veloe01260 mutant neuroblast clones projection neuron cell numbers are drastically reduced from ~35 neurons in wild-type to an average of 5.5 neurons.

      (Berdnik et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of CG12717Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GH146 suppresses the DL1 projection neuron mistargeting phenotype found in veloe01260 mutants. However, veloe01260 mutant axon phenotypes cannot be reverted by CG12717Scer\UAS.T:Ivir\HA1 expression.

      Expression of Ulp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GH146 suppresses the DL1 projection neuron mistargeting phenotype found in veloe01260 mutants. However, veloe01260 mutant axon phenotypes cannot be reverted by CG12717Scer\UAS.T:Ivir\HA1 expression.

      The number of veloe01260 mutant neuroblast clone projection neuron cells is increased upon Ulp1Scer\UAS.T:Ivir\HA1 or CG12717Scer\UAS.T:Ivir\HA1 expression (under the control of Scer\GAL4GH146). However, the overall number is still lower than in wild-type.

      (Berdnik et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Not rescued by

      veloe01260 is not rescued by veloC1624S.UAS.Tag:HA/Scer\GAL4GH146

      (Berdnik et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on dendrite targeting defects in the antennal lobe, the following velo alleles can be ranked from most severe to weakest as follows: veloe01260 > veloLL05209 > veloLL05207.

      (Berdnik et al., 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG10107e01260
      veloe01260
      Name Synonyms
      Secondary FlyBase IDs
        References (2)