FB2026_02 , released June 18, 2026
Allele: Dmel\Atf-2c06407
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General Information
Symbol
Dmel\Atf-2c06407
Species
D. melanogaster
Name
FlyBase ID
FBal0188163
Feature type
allele
Associated gene
Dmel\Atf-2
Associated Insertion(s)
PBac{PB}Atf-2c06407
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Seong et al., 2011)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Atf-2c06407
Cytology
Description

Insertion of PBac{PB} 69 bp upstream of the Atf-2 translation initiation codon.

(Seong et al., 2011)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Atf-2c06407 mutant flies are more resistant to Ecc15 infection than wild-type flies and exhibit lower levels of reactive oxygen species in the intestine following infection. Atf-2c06407 mutant flies accumulate lipids in the R2b and R5 regions of the midgut.

      (Chakrabarti et al., 2014)

      Atf-2c06407 heterozygotes and homozygotes relieve w silencing in the In(1)wm4 line in a dose-dependent manner.

      Animals that are either maternally or zygotically mutant for Atf-2c06407 show derepression of w in In(1)wm4, and the loss of both maternal and zygotic Atf-2 has an additive effect.

      In contrast to controls, Atf-2c06407 mutant flies do not show relieved w silencing in the In(1)wm4 line when embryos are exposed to heat-shock 0-3 hours after egg laying.

      (Seong et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Atf-2c06407 has suppressor of variegation phenotype, enhanceable by spn-E1/spn-E[+]

      (Seong et al., 2011)

      Atf-2c06407 has suppressor of variegation phenotype, enhanceable by aub[+]/aubQC42

      (Seong et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When Atf-2c06407/+ is combined with spn-E1/+ or aubQC42/+, an additive effect on the derepression of w in In(1)wm4 flies is observed.

      (Seong et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Atf-2c06407
      dATF-2PB
      (Seong et al., 2011)
      dATF2PB
      (Santabárbara-Ruiz et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)