FlyBase Allele Report: Dmel\lep[3c5]

General Information

Symbol

Dmel\lep^3c5

Species

D. melanogaster

Name

FlyBase ID

FBal0189829

Feature type

allele

Associated gene

lep

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Coelho et al., 2005)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with lep^3c6)

(Coelho et al., 2005)

lethal | recessive

(Coelho et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes do not have a Minute bristle phenotype. Homozygous clones in the eye are recovered at a reduced frequency and size compared to their twin spots. Cell size is not detectably reduced in the surviving homozygous clones compared to neighbouring wild-type cells.

(Coelho et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lep^3c5/lep[+] is an enhancer of visible phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

lep^3c5/lep[+] is an enhancer of visible phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

Other

Statement

Reference

E-3c1¹, lep^3c5/lep[+] has decreased body size | dominant phenotype

(Coelho et al., 2005)

E-3c4⁴, lep^3c5/lep[+] has lethal | dominant phenotype

(Coelho et al., 2005)

E-3c7⁷, lep^3c5/lep[+] has decreased body size phenotype

(Coelho et al., 2005)

E-3c4[+]/E-3c4⁴, lep^3c5 has lethal phenotype

(Coelho et al., 2005)

lep^3c5, pix^3c2/pix[+] has lethal phenotype

(Coelho et al., 2005)

E-3c1[+]/E-3c1¹, lep^3c5 has decreased body size phenotype

(Coelho et al., 2005)

lep^3c5, pix^3c3/pix[+] has decreased body size phenotype

(Coelho et al., 2005)

E-3c7⁷/E-3c7[+], lep^3c5 has decreased body size | dominant phenotype

(Coelho et al., 2005)

lep^3c5/lep[+], pix^3c2 has lethal | dominant phenotype

(Coelho et al., 2005)

lep^3c5/lep[+], pix^3c3 has decreased body size | dominant phenotype

(Coelho et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

lep^3c5/lep[+] is an enhancer of wing phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

lep^3c5/lep[+] is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Coelho et al., 2005)

NOT Enhancer of

Statement

Reference

lep^3c5/lep[+] is a non-enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Coelho et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

lep^3c5 dominantly enhances the small wing phenotype caused by expression of argos^Scer\UAS.cMa under the control of Scer\GAL4^Bx-MS1096, but does not enhance the argos^Scer\UAS.cMa ; Scer\GAL4^Bx-MS1096 wing vein loss phenotype.

(Coelho et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^Bx-MS1096.

(Coelho et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E-3c⁵

(Coelho et al., 2005)

lep^3c5

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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