FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lam9
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General Information
Symbol
Dmel\Lam9
Species
D. melanogaster
Name
FlyBase ID
FBal0190395
Feature type
allele
Associated gene
Dmel\Lam
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Osouda et al., 2005)
Mutagen
P-element activity
(Osouda et al., 2005)
Progenitor genotype
P{lacW}LamP
(Osouda et al., 2005)
Cytology
Description

Imprecise excision of the P{lacW} element, resulting in the removal of 2255bp of Lam, which corresponds to the N-terminal 536 amino acid residues of the Lam protein, including the translational start site.

(Osouda et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The majority of Lam9 mutants die at the pharate adult stage and the rest die throughout the pupal stage. Mutants that survive to the pharate adult stage show developmental defects. The nuclear envelope is abnormal in the larval CNS of Lam9 mutants; nucleoporins are clustered, although the structure of individual nucleoporins is normal. Clustering coincides with an absence of LamC protein. Additionally, Lam9 eyes show a nuclear migration defect. The ventriculus of Lam9 mutants is ~3- to 5-fold larger than wild type.

      (Osouda et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Lam9 is rescued by Lam+tLa

      (Osouda et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lam9
      lam9
      (Osouda et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)