FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mps1A15
Open Close
General Information
Symbol
Dmel\Mps1A15
Species
D. melanogaster
Name
FlyBase ID
FBal0190500
Feature type
allele
Associated gene
Dmel\Mps1
Associated Insertion(s)
Doc{}A15
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Nielsen et al., 2006)
Progenitor genotype
Associated Insertion(s)
Doc{}A15
Cytology
Description

The Doc{}A15 insertion is 5' truncated by 827bp and is located in the 4th/5th exon (depending on isoform) of alt, oriented in the sense direction of the alt transcription unit. This insertion affects expression of alt and also neighboring downstream genes; 0-2 hour embryos from eggs laid by females homozygous for the Doc{}A15 insertion show no expression of alt, Mps1 or CG7523 mRNA (in contrast to wild-type controls).

(Miller et al., 2023)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Mps1ald-1

      (Page et al., 2007)
      Rescued by

      Mps1A15 is rescued by Mps1+t4.2

      (Page et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Although the Doc{}altA15 insertion is within alt, evidence suggests that the mutant phenotype caused by the insertion is due to an effect on the upstream gene, ald, and not due to an effect on alt; the Doc{}altA15 chromosome fails to complement ald1 and is rescued by ald+t4.2, and altexcision18 (a mutation affecting only alt) complements the meiotic nondisjunction phenotype of the Doc{}altA15 chromosome.

      (Page et al., 2007)

      Associated with: altA15.

      (Page et al., 2007)

      FlyBase curator comment: two alleles are associated with Doc{}altA15 in the database; altA15, which represents the insertion within the alt transcription unit, and aldA15, which represents the mutant phenotype caused by the effect of the insertion on the ald gene.

      (Page et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mps1A15
      (Miller et al., 2023)
      aldA15
      (Page et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)