FB2026_02 , released June 18, 2026
Allele: Dmel\Cp190ΔM.Ubi-p63E
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General Information
Symbol
Dmel\Cp190ΔM.Ubi-p63E
Species
D. melanogaster
Name
FlyBase ID
FBal0190637
Feature type
allele
Associated gene
Dmel\Cp190
Associated Insertion(s)
Carried in Construct
P{Ubi-Cp190.ΔM}
Also Known As
Cp190ΔM
Key Links
Transgenic product class
inframe_deletion
(Butcher et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Butcher et al., 2004)
Mutagen
in vitro construct
(Butcher et al., 2004)
Progenitor genotype
Carried in construct
P{Ubi-Cp190.ΔM}
Cytology
Description

Construct: A Ubi-p63E promoter drives expression of Cp190, which lacks amino acid residues 311-541 (thus the expressed protein has no centrosomal or microtubule targeting domain).

(Butcher et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
Cp190
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Unlike the wild-type protein, the Cp190ΔM.Ubi-p63E protein is unable to interact with microtubules or centrosomes.

      (Butcher et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Cp190ΔM.Ubi-p63E has lethal | recessive | pupal stage phenotype, suppressible by Map60Ubi-p63E.PB

      (Butcher et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying two copies of the Cp190ΔM.Ubi-p63E transgene, that normally show homozygous lethality, are viable as adults if they also carry a copy of the Map60Ubi-p63E.PB transgene.

      (Butcher et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Cp190ΔM.Ubi-p63E rescues Cp1903

      (Oliver et al., 2010)
      Partially rescues

      Cp190ΔM.Ubi-p63E partially rescues Cp1902

      (Chodagam et al., 2005)

      Cp190ΔM.Ubi-p63E partially rescues Cp1901

      (Butcher et al., 2004)

      Cp190ΔM.Ubi-p63E partially rescues Cp1902

      (Butcher et al., 2004)
      Comments

      Expression of Cp190ΔM.Ubi-p63E rescues the lethality of homozygous Cp1903.

      (Oliver et al., 2010)

      Expression of the Cp190ΔM.Ubi-p63E transgene fails to rescue the axial-expansion defect of Cp1902 flies.

      (Chodagam et al., 2005)

      The Cp190ΔM.Ubi-p63E transgene rescues the lethality of Cp1902 mutants so that ~80% of flies survive to adulthood. However, these adults are unhealthy and only survive for a few days.

      (Butcher et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cp190ΔM.Ubi-p63E
      Cp190ΔM
      (Butcher et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)