FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mib1L53
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General Information
Symbol
Dmel\mib1L53
Species
D. melanogaster
Name
FlyBase ID
FBal0190648
Feature type
allele
Associated gene
Dmel\mib1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Wang and Struhl, 2005)
Mutagen
ethyl methanesulfonate
(Wang and Struhl, 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q1163term.

(Wang and Struhl, 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,006,986..16,006,986 [-]
Nucleotide change:

C16006986T

Amino acid change:

Q1163term | mib1-PA; Q1052term | mib1-PB

Reported amino acid change:

Q1163term

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

(Wang and Struhl, 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mib1L53/mib1L70 transheterozygotes have abnormally small wing and eye imaginal discs and die as pupae. mib1L53 homozygotes die as first instar larvae. mib1L53 wing clones are associated with wing notching and vein thickening. mib1L53 female germ cell clones can survive until the pupal stage, with some of these differentiating into pharate adults. These show severely truncated wings, consisting only of small stumps of wing hinge tissue, as well as an abnormally high density of microchaetes and occasional duplication of macrochaetes on the mesonotum. In addition, such mutant animals develop only rudimentary eyes containing around ~25-50 ommatidia and form legs with truncated and fused leg segments.

      (Wang and Struhl, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dmibL53
      (Wang and Struhl, 2005)
      mib1L53
      Name Synonyms
      Secondary FlyBase IDs
        References (1)