FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Elp62
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General Information
Symbol
Dmel\Elp62
Species
D. melanogaster
Name
FlyBase ID
FBal0190755
Feature type
allele
Associated gene
Dmel\Elp6
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The polytenic nurse cells of early-stage poly2 germ-line clones are indistinguishable from those of wild-type, but after stage 5 poly2 clones remain arrested in the distinct five-blob configuration of stage 4.

        Homozygous poly2 and transheterozygous poly2/poly1 larvae exhibit delayed development, reaching third-instar and pupal stages later than their heterozygous siblings.

        poly2 mutant mothers and poly2 germ-line mutant mothers drived from the dominant female sterile technique both fail to deposit eggs.

        poly2 homozygotes and poly2/poly1 transheterozygotes display notching of the wing margin.

        Homozygous poly2 and transheterozygous poly1/poly2 mutant ovaries are small and display a wide variety of defects, including egg-chamber fusion, apoptosis and nurse cell chromosome morphology defects.

        (Klusza and Deng, 2010)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        A Hrb27C377 heterozygous background strengthens the wing margin phenotype found in poly2 homozygous mutants (compared to a wild-type background).

        There are no changes in nurse cell chromosomal dispersal in otu13/+; poly2 germ-line clones.

        Multiple copies of the otu104 transgene facilitate further development of poly2 homozygous ovaries.

        (Klusza and Deng, 2010)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Elp62 is rescued by Scer\GAL4Act5C.PI/Elp6UASp.cKa

        (Klusza and Deng, 2010)

        Elp62 is rescued by Elp6UASp.EGFP/Scer\GAL4VP16.mat.αTub67C

        (Klusza and Deng, 2010)
        Comments

        The wing margin phenotype found in poly2 homozygotes is alleviated upon expression of polyScer\UAS.P\T.cKa under the control of Scer\GAL4Act5C.PI.

        (Klusza and Deng, 2010)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Selected as: a mutation in which posterior stau localization is disrupted in stage 9 female germ-line clones.

        (Klusza and Deng, 2006)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        8131
        (Klusza and Deng, 2010)
        Elp62
        poly2
        (Klusza and Deng, 2010, Klusza and Deng, 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)