FlyBase Allele Report: Dmel\Bre1[ΔRING.UAS]

General Information

Symbol

Dmel\Bre1^ΔRING.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0190872

Feature type

allele

Associated gene

Dmel\Bre1

Associated Insertion(s)

Carried in Construct

P{UAS-ΔRING.Bre1}

Key Links

Transgenic product class

inframe_deletion

(Bray et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Bray et al., 2005)

Mutagen

in vitro construct

(Bray et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-ΔRING.Bre1}

Cytology

Description

UASt regulatory sequences drive expression of N-terminal Bre1 coding sequence lacking the RING domain (991-1029 residues).

(Bray et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Bre1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing, with Bre1⁰¹⁶⁴⁰, Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

wing, with Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

wing vein, with Bre1⁰¹⁶⁴⁰, Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

Detailed Description

Statement

Reference

Bre1^{ΔRING.Scer\UAS} expression under the regulation of Scer\GAL4^Bx-MS1096 results in upward-curved wings, tiny vein deltas, and a significant decrease in wing size, in both males and females. These phenotypes are more severe in a Bre1⁰¹⁶⁴⁰ heterozygous background.

(Bray et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing vein | ectopic phenotype of Delta^RF

(Bray et al., 2005)

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing phenotype of Delta^RF

(Bray et al., 2005)

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing vein phenotype of Delta^RF

(Bray et al., 2005)

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing vein | ectopic phenotype of N^55e11

(Bray et al., 2005)

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing phenotype of N^55e11

(Bray et al., 2005)

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS is an enhancer of wing vein phenotype of N^55e11

(Bray et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Bre1^{ΔRING.Scer\UAS}, under the regulation of Scer\GAL4^Bx-MS1096 enhances the phenotype of N^55e11/+ and Dl^RF/+, resulting in an increase in the thickness of wing veins and additional vein material. In the case of N^55e11/+ an increase in wing notching is also found.

(Bray et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS fails to rescue Bre1⁰¹⁶⁴⁰

(Bray et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bre1^{ΔRING.Scer\UAS}

Bre1^ΔRING.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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