FlyBase Allele Report: Dmel\Bre1[01640]

General Information

Symbol

Dmel\Bre1⁰¹⁶⁴⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0009420

Feature type

allele

Associated gene

Dmel\Bre1

Associated Insertion(s)

P{PZ}Bre1⁰¹⁶⁴⁰

Carried in Construct

Also Known As

l(3)01640

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Bre1⁰¹⁶⁴⁰

Cytology

Description

The insertion site is 48 nucleotides upstream of the translation initiation codon.

(Bray et al., 2005)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:5,793,892..5,793,892 [+]

(Bray et al., 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell growth

(Bray et al., 2005)

lethal

(Bray et al., 2005)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

eye | somatic clone

(Bray et al., 2005)

leg | somatic clone

(Bray et al., 2005)

macrochaeta, with Bre1^UAS.fl, Scer\GAL4^arm.PS

(Bray et al., 2005)

tarsal segment | somatic clone

(Bray et al., 2005)

wing, with Bre1^ΔRING.UAS, Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

wing | somatic clone

(Bray et al., 2005)

wing margin bristle | somatic clone

(Bray et al., 2005)

wing vein, with Bre1^ΔRING.UAS, Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

wing vein | somatic clone

(Bray et al., 2005)

Detailed Description

Statement

Reference

Bre1⁰¹⁶⁴⁰ mutant clones exhibit notches in the wing margin, aberrant spacing of wing margin bristles, wing blistering and vein defects, fusions of leg segments, and loss of notal bristles and rough eyes.

Bre1⁰¹⁶⁴⁰ mutant clones are considerably smaller than their matched wild-type twin clones.

Ubiquitous expression of Bre1^Scer\UAS.fl, under the regulation of Scer\GAL4^arm.PS rescues the lethality of Bre1⁰¹⁶⁴⁰ mutant embryos and sustains development to give essentially normal adult flies (with a few minor defects including slightly reduced bristles).

Bre1^{ΔRING.Scer\UAS}/Scer\GAL4^Bx-MS1096 phenotypes of upward-curved wings, tiny vein deltas, and a significant decrease in wing size, in both males and females are more severe in a Bre1⁰¹⁶⁴⁰ heterozygous background.

(Bray et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Bre1[+]/Bre1⁰¹⁶⁴⁰ is an enhancer of chemical sensitive | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

Bre1[+]/Bre1⁰¹⁶⁴⁰ is an enhancer of increased mortality | adult stage phenotype of Otud6^C183A

(Villa et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bre1⁰¹⁶⁴⁰ is rescued by Bre1^UAS.fl/Scer\GAL4^arm.PS

(Bray et al., 2005)

Not rescued by

Bre1⁰¹⁶⁴⁰ is not rescued by Scer\GAL4^Bx-MS1096/Bre1^ΔRING.UAS

(Bray et al., 2005)

Rescues

Bre1⁰¹⁶⁴⁰/Scer\GAL4^Bx-MS1096 rescues Bre1^UAS.fl

(Bray et al., 2005)

Comments

Vein defects in Bre1^Scer\UAS.fl/Scer\GAL4^Bx-MS1096 male wings are rescued to an almost wild-type phenotype in Bre1⁰¹⁶⁴⁰ heterozygotes.

(Bray et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11541

P{PZ}Bre1⁰¹⁶⁴⁰ ry⁵⁰⁶/TM6B, ry^CB Tb⁺

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(3)02331⁰²³³¹. Complements: l(3)05143⁰⁵¹⁴³. Complements: vn¹⁰⁵⁶⁷. Complements: vn^rF264.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Bre1⁰¹⁶⁴⁰

Bre1^PZ

(Villa et al., 2024)

E132

P1541

l(3)01640

(Mohan et al., 2010, Spradling et al., 1999)

l(3)01640⁰¹⁶⁴⁰

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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