FlyBase Allele Report: Dmel\Bre1[UAS.fl]

General Information

Symbol

Dmel\Bre1^UAS.fl

Species

D. melanogaster

Name

FlyBase ID

FBal0190408

Feature type

allele

Associated gene

Dmel\Bre1

Associated Insertion(s)

Carried in Construct

P{UAS-Bre1}

Key Links

Transgenic product class

wild_type

(Bray et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Bray et al., 2005)

Mutagen

in vitro construct

(Bray et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Bre1}

Cytology

Description

UAS regulatory sequences drive expression of full-length Bre1 coding sequence.

(Bray et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Bre1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

macrochaeta, with Bre1⁰¹⁶⁴⁰, Scer\GAL4^arm.PS

(Bray et al., 2005)

wing vein, with Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

Detailed Description

Statement

Reference

Bre1^Scer\UAS.fl expression, under the regulation of Scer\GAL4^Bx-MS1096 results in vein thickening and additional vein material only in males, while female wings are less affected, in some individuals appearing wild-type. These vein defects in male wings are rescued to an almost wild-type phenotype in Bre1⁰¹⁶⁴⁰ heterozygotes. Ubiquitous expression of Bre1^Scer\UAS.fl, under the regulation of Scer\GAL4^arm.PS rescues the lethality of Bre1⁰¹⁶⁴⁰ mutant embryos and sustains development to give essentially normal adult flies (with a few minor defects including slightly reduced bristles).

(Bray et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Bre1^UAS.fl, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by N^55e11

(Bray et al., 2005)

Bre1^UAS.fl, Scer\GAL4^Bx-MS1096 has wing vein | ectopic phenotype, enhanceable by N^55e11

(Bray et al., 2005)

Bre1^UAS.fl, Scer\GAL4^Bx-MS1096 has wing vein | ectopic phenotype, enhanceable by Delta^RF

(Bray et al., 2005)

Bre1^UAS.fl, Scer\GAL4^Bx-MS1096 has wing vein phenotype, enhanceable by Delta^RF

(Bray et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The vein thickening and additional vein material phenotype of flies expressing Bre1^Scer\UAS.fl, under the regulation of Scer\GAL4^Bx-MS1096 is enhanced in N^55e11 or Dl^RF heterozygotes.

(Bray et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Bre1^UAS.fl is rescued by Bre1⁰¹⁶⁴⁰/Scer\GAL4^Bx-MS1096

(Bray et al., 2005)

Rescues

Bre1^UAS.fl/Scer\GAL4^arm.PS rescues Bre1⁰¹⁶⁴⁰

(Bray et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Bre1^Scer\UAS.fl is expressed in S2 cells to assess the effect of Bre1 on N-dependent transcription.

(Bray et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bre1^Scer\UAS.fl

Bre1^UAS.fl

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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