FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PrmS-A3.cLa
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General Information
Symbol
Dmel\PrmS-A3.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0190943
Feature type
allele
Associated gene
Dmel\Prm
Associated Insertion(s)
Carried in Construct
P{Prm.S-A3}
Key Links
Transgenic product class
missense_variant
(Liu et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Liu et al., 2005)
Mutagen
in vitro construct
(Liu et al., 2005)
Progenitor genotype
Prm+tMa
(Liu et al., 2005)
Carried in construct
P{Prm.S-A3}
Cytology
Description

Construct: Amino acid replacement: S10A. Amino acid replacement: S13A. Amino acid replacement: S18A.

(Liu et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
Prm
Encoded product / tool
Prm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying the PrmS-A3.cLa transgene exhibit significant defects in flight ability compared to wild-type. However, the indirect flight muscle myofibrils of these mutants are assembled normally. There aren't any significant differences between control and mutant flies in major structural parameters such as sarcomere length, thick filament number per myofibril cross-sectional area, and percentage of myofibril area per muscle cross-sectional area. Mutant flies exhibit a 1.4-2.7% increase in myofibril cross-sectional area, although the number of thick filaments per fiber is unchanged.

      (Liu et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      PrmS-A3.cLa rescues Prm1

      (Liu et al., 2005)
      Comments

      The transgene PrmS-A3.cLa rescues the embryonic lethal phenotype of Prm1 to adulthood.

      (Liu et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PrmS-A3.cLa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)