FB2026_03 , released September 17, 2026
Allele: Dmel\Prm1
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General Information
Symbol
Dmel\Prm1
Species
D. melanogaster
Name
FlyBase ID
FBal0182149
Feature type
allele
Associated gene
Dmel\Prm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Liu et al., 2003)
Progenitor genotype
PrmS010605
(Liu et al., 2003)
Cytology
Description

As a result of a PCR artifact and an error in notation, the deletion in the Prm1 allele was stated to be 4kb in size in FBrf0159031. Reanalysis of the data, as well as additional cloning and sequencing indicate that the deletion is actually 1.05kb in length and is internal to the P-element. The deleted region encompasses portions of the upstream region and first exon of the w gene, removing 163 codons.

(Liu et al., 2004)

FlyBase curator comment: FBrf0159031 states that the lesion in Prm1 is the deletion of a 4kb fragment 5' to the second nucleotide of the transcription start site. However, this is in error - see FBrf0184062 for subsequent revision of this data.

(Liu et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The authors retract the statement in FBrf0159031 that Prm1 homozygotes exhibit a myoblast fusion phenotype. Experiments subsequent to publication now indicate that this phenotype may be due to a TM3 balancer that was mis-indentified.

      (Liu et al., 2004)

      The banding patterns of myosin and actin in Prm1 homozygous mutant embryo wall muscles is completely disrupted. In wild-type, well-organised sarcomeres are formed in somatic muscle fibers. Sarcomeres are severely disrupted in Prm1 mutant embryos, Z-bodies are poorly organised, the length of myofilaments are greatly reduced and bundles of myofilaments associated with these Z-bodies are not parallel. Prm1 homozygous mutant embryos have reduced thick filament numbers. However, thin filament number in the same area is relatively unaffected. This leads to some areas of myofibrils completely lacking thick filaments. Compared to wild-type, thick filaments of Prm1 embryo body wall muscles are solid. Dense particles in the periphery collapse into the center, forming filled thick filaments. The diameters of thick filaments are also not even.

      (Liu et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Prm1 is rescued by PrmS-A3.cLa

      (Liu et al., 2005)

      Prm1 is rescued by PrmS18A.cLa

      (Liu et al., 2005)

      Prm1 is rescued by PrmS-A4.cLa

      (Liu et al., 2005)

      Prm1 is rescued by PrmS10A.cLa

      (Liu et al., 2005)

      Prm1 is rescued by Prm+tMa

      (Liu et al., 2003)
      Comments

      The transgenes PrmS10A.cLa, PrmS18A.cLa, PrmS-A3.cLa, and PrmS-A4.cLa rescue the embryonic lethal phenotype of Prm1 to adulthood.

      (Liu et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Prm1
      prm1
      (Liu et al., 2005, Liu et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)