FB2026_03 , released September 17, 2026
Allele: Dmel\PrmS10A.cLa
Open Close
General Information
Symbol
Dmel\PrmS10A.cLa
Species
D. melanogaster
Name
FlyBase ID
FBal0190424
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Construct: Amino acid replacement: S10A.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying the PrmS10A.cLa transgene do not exhibit any significant differences in flight ability compared to wild-type. Indeed, the indirect flight muscle myofibrils of these mutants are assembled normally. There aren't any significant differences between control and mutant flies in major structural parameters such as sarcomere length, thick filament number per myofibril cross-sectional area, and percentage of myofibril area per muscle cross-sectional area. Mutant flies exhibit a 1.4-2.7% increase in myofibril cross-sectional area, although the number of thick filaments per fiber is unchanged.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The transgene PrmS10A.cLa rescues the embryonic lethal phenotype of Prm1 to adulthood.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
PrmS10A.cLa
Name Synonyms
Secondary FlyBase IDs
    References (1)